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Its promoter region contains eight stress-responsive cis-acting elements linked to phytohormones and stress pathways, including abscisic acid, MeJA (methyl jasmonate), gibberellin and salicylic acid ( III stress and reduces levels of the lipid peroxidation marker MDA, highlighting its potential as a target for crop improvement ( Arabidopsis , mirroring the function of mammalian CHAC2 ( AtGGCT2;2 contains cis-elements responsive to auxin, MeJA and low temperature

The first identified and widely recognized metabolic reprogramming pathway is the Warburg effect - a phenomenon that involves the increase in glucose consumption rate and its fermentation to lactate in tumors, even in the presence of oxygen [14, 15]

Horsley et al., 2013)

Since 2004, the representative first-generation nucleosides DNMTi, 5-azacitidine, clofarabine, and decitabine have been approved by the FDA for the treatment of MDS, CMML, and AML

Naviaux JC, Schuchbauer MA, Li K, Wang L, Risbrough VB, Powell SB, et al