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In mammalian cells, it is encoded from the mitochondrial DNA and under stress conditions, it then translocates to the nucleus, which is accompanied by higher ROS production [21]

5: Rahman OF, Lee SJ, Seeds WA

When LYMErix became available in 1998, I was already treating patients with Lyme disease in clinical practice

Using a flow cytometry-based assay for intracellular glutathione, we found that although melatonin increased cellular GSH levels, this effect was lost when cells were co-treated with melatonin and IKE ( Figure 6I )