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Perioperative analgesia associated with oral administration of a novel methadone-fluconazole-naltrexone formulation in dogs undergoing routine ovariohysterectomy

doi:10.1345/aph.1Q629

Does it have a known receptor

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In human clinical use, reported side effects are generally mild and transient: Mild injection site redness or discomfort (resolves within hours) Transient nausea in some patients, particularly early in the protocol Mild dizziness or light-headedness (rare, typically dose-related) Temporary fatigue in the first few days (often a sign of active tissue remodeling) No significant systemic toxicity, organ damage, hormonal suppression, or addiction potential has been documented in the published literature

Incubation was done at 37 C for 20 min