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Alkylamine-based degraders functionally depend on FBXO22 To explore the potential generalizability of exploiting FBXO22 for targeted protein degradation, we extended our experiments to two recently reported primary alkylamine-tethered degraders targeting either NSD2 or XIAP, as well as a set of alkylamine-tethered analogues targeting BRD4 (Fig

It is estimated over 37,000 pancreatic cancer cases will be annually recognized that leading to 34,000 fatalities

however, the difference was not statistically significant (Table 2)

PMCID: PMC11687131

Prior to joining the team, she worked as Us Weeklys Beauty and Style Editor, where she stayed on the pulse of pop culture and broke down celebrity beauty routines, hair transformations, and red carpet looks

More clinical evaluations are needed to firmly establish the role of DSIP in human sleep and central nervous system disorders