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Together, this evidence suggests that stress-induced BBB dysfunction associated with combat may have allowed pyridostigmine to penetrate the brain and exert central neurotoxic effects that are characteristic of Gulf War Syndrome

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Interestingly, GSTO1 polymorphisms and decreased expression have been implicated in several pathological conditions such as Parkinsons and Alzheimers disease 7

When amyloid beta interacts with microglial receptors, it triggers an inflammatory response characterized by the release of pro-inflammatory cytokines like TNF-alpha, IL-1beta, and IL-6 (107)