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( D and E ) Hb to RDW ratio and annexin-V + RBCs from WT and 4.2 / mice with or without spleen and treated with either vehicle or mitapivat (100 mg/kg/d)

Some focus on small-scale microscopic details, while others examine larger-scale tissue healing

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We found that three of the model-designed sequences are potent dual agonists with superior biological activity