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doi:10.2169/internalmedicine.49.3509

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Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate to severe plaque psoriasis over 52 weeks: a phase III, randomized, controlled trial (ESTEEM 2)

Week 4-6: Early responders start seeing fine vellus hairs (baby hairs) emerging , especially around the hairline

While genetic association studies for common variants in the GDNF gene have been underpowered for tinnitus, plasma biomarker studies have identified GDNF among top circulating proteins associated with constant tinnitus, though these associations did not survive strict multiple testing corrections (Amanat et al., 2021