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For example, renal endothelial cells (critical for maintaining microvascular integrity) or mesangial cells may also undergo ferroptosis in response to contrast agents, yet their role in amplifying CIN injury (e.g., via paracrine signaling or microvascular rarefaction) has not been rigorously characterized

Often the distance gap between a 5-iron and 4-iron is negligible and the key difference is height

and PTEN-induced putative kinase 1 (PINK1), which works in concert with PARKIN to identify and eliminate damaged mitochondria