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This redundancy, combined with the fact that inhibition of hexokinase would confer severe side effects on normal, hexokinase-expressing tissues, probably accounts for their failure in clinical trials 192

Inhibition of superoxide dismutase by 2methoxyoestradiol analogues and oestrogen derivatives: structureactivity relationships

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Severe combined immunodeficient (SCID), non-obese/diabetic (NOD)/SCID, athymic nude, and NSG mice are typical hosts for PDX development, due to their impaired immune systems, which facilitates achieving graft survival without risk of short-term rejection

Nanovaccines represent a major class of systemic immune-priming platforms