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They had observed that 10 mol/L curcumin, when incubated with a vincristine-resistant gastric carcinoma cell line, could downregulate the expression of P-gp, in addition to promoting caspase-3 activity in MDR cells [236]

Alkoxyl radicals (RO) RO are a class of organic radicals that emerge from the decomposition of RO, predominantly formed during lipid metabolism and oxidative stress responses, especially in lipid-rich areas such as cell membranes and mitochondria [66]

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The timeline reflects the biological mechanism: sermorelin stimulates pulsatile HGH secretion within hours, but downstream tissue-level effects IGF-1 synthesis, protein accretion, lipolysis require weeks to manifest