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80 Cutaneous ulcers are strongly associated with ILD development and serve as an independent risk factor for pneumomediastinum in anti-MDA5 DM patients

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Evidence from numerous studies suggests that long-term exposure to CaOx promotes M1 polarization, characterized by pro-inflammatory cytokine secretion (IL-6, IFN-, TNF-) and adhesion molecule expression (VCAM-1), thereby propagating inflammatory cascades that facilitate stone formation [11,12,13]

In skincare products, GHK-Cu is often used at concentrations ranging from 0.1% to 3% for its skin-regenerating and anti-aging effects

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55 Gonzlez-ArzolaK.Daz-MorenoI.Cano-GonzlezA.Daz-QuintanaA.Velzquez-CampoyA.Moreno-BeltrnB.et al (2015)