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Corkey, [email protected] This article was submitted to Fractal and Network Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

PCBP1 and PCBP2 are expressed at high levels in essentially all mammalian cell types, while PCBP3 and PCBP4 exhibit much lower levels of expression in a limited range of tissues

Some studies suggest BPC-157 may be useful for traumatic brain injuries (TBI) or stroke recovery, though more research is needed in these areas

Because the BPC-157 peptide operates through VEGFR2 and NO pathways that are mechanistically distinct from TB-500s actin-based signaling and GHK-Cus collagen synthesis mechanisms, the three compounds address complementary aspects of tissue repair without documented antagonism in animal studies

However, unmodified fragments suffered from rapid degradation and short half-life

Medications with a narrow therapeutic index or those requiring rapid onset of action may be particularly affected