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In 2023, Lopez-Otin proposed twelve markers of aging, including genomic instability, telomere loss, epigenetic changes, loss of protein balance, failure of macroautophagy, dysregulated nutrient sensing, mitochondrial dysfunction, cell senescence, stem cell depletion, altered intercellular communication, chronic inflammation, and dysbiosis

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Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O

T.CoombesJ

Animal studies have reported observations of altered body composition and reduced adiposity in NNMT-inhibited models

Histology showed Dox-induced myocardial remodeling and inflammation, which were attenuated by all treatments, restoring cardiomyocyte occupancy, reducing extracellular matrix expansion, and decreasing inflammatory infiltrate