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The growth arrest was presumably caused by upregulation of cyclin-dependent kinase inhibitors that suggest the possibility of using colostrum for reducing the proliferation of keratinocytes in the treatment of skin diseases characterized by a disturbed skin barrier and altered differentiation [46]

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During tretinoin treatment, cells expressing PML/RAR-alpha undergo cellular differentiation at a rate higher than normal cells

These controversies underscore the pressing need for transparent, independent research and standardized methodologies to enhance the reliability and policy relevance of findings