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Experiments carried out on cells cultured in vitro have shown that both bilirubin and biliverdin are endogenous agonists of the AhR (97)

However, the potential of B12 status as an acute phase reactant requires further study

Monitor baseline GH, IGF-1, and sex hormones before and during treatment

In a similar study, no chromosomal aberrations were observed in the bone marrow cells of male Purina Caesarean-derived albino rats exposed to aspartame at 500, 1000, 2000, or 4000 mg/kg bw per day by oral gavage for 5 days (EFSA_E43, 2011)

Regev Elya Vitamin B12 has an excellent tolerability and absolutely no known toxic overdose levels

Faiq et al., 2013b