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The problem with grouping people in this way, however, is that there may be selection biases differences between the groups which could influence the results of the study such as personality types of people who are keen to participate in interventions versus those who are not, or unintended differences in access to the intervention due to location

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When an individual is faced with a stressor, the hypothalamus releases corticotropin-releasing hormone (CRH), which stimulates the anterior pituitary gland to secrete adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce cortisol, which plays a key role in the stress response [75,76]