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406 UPS-targeting peptides and engineered ubiquitin variants further expand therapeutic possibilities by selectively modulating E3 ligases or DUBs

Probiotics can enhance vitamin D receptor (VDR) protein expression, improving active vitamin D absorption, which acts in turn to potentiate immune response regulation (187)

4.4 Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder that results from the progressive loss of upper and lower motor neurons that control voluntary movement (10)

Cells were grown overnight, reinoculated in fresh medium and further grown for 8 h

30 mg/kg) for 12 weeks attenuated retinal vascular degeneration, prevented the reduction of retinal thickness, and improved retinal function in db/db mice (Zhou et al., 2019)