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It is evident that the blood-brain barrier is crossed by a passive flux of oxysterols, but not of cholesterol per se, as a result of their higher polarity and permissive chemical structures and following their concentration gradients

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This heterogeneity and poorly understood neurobiology pose significant challenges to existing drug development paradigms, resulting in scarce treatment options, especially for bipolar depression

Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy