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MOTS-c has a half-life of 46 hours and works best when administered during metabolic windows where AMPK activation is already primedfasted states, pre-training, or during caloric deficit periods

Evidence grade Preclinical evidence only Regulatory status No FDA-approved indication and no exact-name ClinicalTrials.gov record located as of July 12, 2026

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(2001) demonstrated that AOD-9604 in isolated rat adipocytes increases lipolysis by ~150 % over baseline, comparable to full hGH stimulation, but without any effect on cellular proliferation

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