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Intervention studies have shown that supplementation with riboflavin (the MTHFR cofactor) effectively lowers blood pressure, specifically in individuals with the variant MTHFR 677TT genotype

Decreased intracellular levels of flavocoenzymes could cause mitochondrial dysfunction, increase oxidative stress, and interfere with nitric oxide release and thus blood vessel dilation all of these changes have been associated with preeclampsia (26)

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It may be tempting to reach for skin lightening treatments, however, those such as hydroquinone and its natural derivative arbutin should be avoided in pregnancy because of high systemic absorption

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