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GH SIGNALING Data on GHR signaling derive mainly from rodent models and experimental cell lines, although GH-induced activation of the JAK2/STAT5b and the MAPK pathways have been recorded in cultured human fibroblasts from healthy human subjects (57)

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In some cases, the drugs contain impurities

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In addition, to transphosphrylation-dependent signaling pathways, the induction of gene expression of proteins involved in cell-associated proteolytic break-down of ECM components plays animportant role in branching tubulogenesis,including uPA, uPA receptor and membrane-type 1 matrix metalloprotease