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Volume 10, Apr

Nrf2 plays a pivotal role in redox homeostasis and is involved in key metabolic processes, including xenobiotic detoxification, iron and heme metabolism, lipid and carbohydrate metabolism, proteostasis, and the regulation of cell death pathways ( The activity of Nrf2 is primarily regulated by Kelch-like ECH-associated protein 1 (Keap1), a cytosolic repressor that acts as a substrate adaptor for a Cullin-3-based E3 ubiquitin ligase complex

Currently, the main combination therapy focuses on vaccine combined with other drugs to enhance the anti-tumor effect

research compound only Main studied indication / GH-IGF axis deficiencies

Data availability The source data for the findings of this study are available from the corresponding author upon reasonable request

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