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98 Moreover, ATOX1 carries copper into the nucleus and functions as a novel transcription factor, thereby contributing to cell proliferation

However, a RCT from this centre, the Folic Acid Supplementation in the Second and Third Trimesters (FASSTT) trial, investigated the effects of extended maternal folic acid supplementation (at the recommended dose of 400 g/d) in trimesters 2 and 3 of pregnancy, and thus beyond the periconceptional period recommended for preventing NTD (Reference McNulty, McNulty and Marshall124)