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16,17 Nevus cells are morphologically and biologically distinct from the melanocytes that are found within the basal layer of the oral epithelium

Immunohistochemical analysis revealed strong cytoplasmic immunoreactivity of dendritic melanocytes for proteinS-100, HMB-45 and melan-A.Positive staining for proliferative markers (MCM-2, MCM-5, Ki-67) was only observed in basal and suprabasal epithelial cells, confirming the reactive etiology of the lesion

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Its classification has been the subject of some debate and histopathologic findings do not always completely resolve clinical uncertainties as they can be indicative of both dysplastic nevus and melanoma.4,810 Clinically, atypical lentiginous nevus manifests as a pigmented lesion located in an area of chronic sun damageprimarily on the back or the proximal parts of the limbsin individuals aged 50 to 70 years

Cadence and dose are calibrated to your individualized protocol