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Omarova Endodontics Today.2021

The IGF/IGF-1R autocrine loop in human BM-MSCs is activated and upregulated by hedgehog signaling, a well-established pathway that is essential for osteoblast differentiation during embryonic skeletal development

It does not directly address dermal papilla cell signaling or follicle stem cell activity

You may be tempted to let it go and allow your dog to work things out themselves, or maybe you're concerned that your attempts to console your dog aren't helping