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IL-6 inhibition Tocilizumab (TCZ) is a humanized monoclonal antibody that targets the IL-6 receptor, which is found on cell surfaces and in circulation

Overexpression of miR-506 in cholangiocytes leads to multiple PBC-like features, including impaired cell proliferation and adhesion, sensitization to bile acid-induced apoptosis, impaired energy metabolism, PDC-E2 overexpression and mislocation into the plasma membrane, and immune activation

Mason JM, Rees GJ

Harland DP, Popescu C, Richena M et al (2022) The susceptibility of disulfide bonds to modification in keratin fibers undergoing tensile stress

Lipids 1865, 158760

But, although these findings imply that the enzyme protects the parasite from oxidative and nitrosoative stresses, the availability of reduced Trx for these activities before 31 HPI when the TrxR transcript peaks, remains to be established