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In the process of metabolizing neurotransmitters, monoamine oxidase B enzyme uses FAD (derived from riboflavin ) and produces hydrogen peroxide .[ref] Excess hydrogen peroxide causes oxidative stress, so MAO-B needs to be maintained at the right levels

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Zhang C, Lu X, Liu X, Xu J, Li J, Qu T, et al

An MAOI (monoamine oxidase inhibitor) like phenelzine prevents the breakdown of serotonin, dopamine, and norepinephrine

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Chemotherapeutic drugs such as methotrexate, 5-fluorouracil, 8-azaguanine, and cisplatin are most affected by this resistance mechanism