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Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States This article was submitted to Hematologic Malignancies, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Lipoic acid is an essential cofactor for mitochondrial metabolism and is required for the catalysis of various mitochondrial 2-keto acid dehydrogenase complexes

In human A-T patient fibroblasts, RNA-immunoprecipitation assays unveiled an increased interaction between PKM2 and the c-Myc mRNA IRES region, hence an elevated c-Myc protein level was detected (Fig