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Notably, many MBP + fibers also stained for human-specific markers for mitochondria and STEM121, indicating that graft-derived OLs were functional and actively producing myelin (Palma-Tortosa et al., 2020)

doi: 10.1038/emm.2014.113 131 JungSHLeeGBRyuYCuiLLeeHMKimJet al

Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease

This results in conformational flexibility of the crossover loop as in the ubiquitin bound structure the crossover loop is displaced away from ubiquitin to make space for the C-terminal tail to thread into the active site ( Figure 6 , red loop)

Dosage decisions should be made in consultation with qualified research oversight, and human application requires appropriate institutional review