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Cell Metabolism 28 (3): 337352

OConnor C, White KL, Doncescu N et al (2015) NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

Among the various compounds tested, PROTACs 62 (DC 50 = 0.11 M, D max = 87%) and 63 (DC 50 = 0.16 M, D max = 85%) stand out with the most robust in vitro cytotoxic effect against FaDu and resistant KM3/BTZ cell lines

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Subsequently, the tissue fragments were inoculated into T75 culture flasks and, once the tissue adhered, the medium was replaced with complete medium (MEM, 20% FBS, 1% PS, 2 g/mL epidermal growth factor EGF, 25 ng/mL fibroblast growth factor FGF) to facilitate cell migration

More detailed information can be found in Figure 1