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Falchook, G

doi: 10.1016/j.intimp.2024.113463 146 SuchanekOFerdinandJRTuongZKWijeyesingheSChandraAClauderAKet al

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E Bio Med

Patient age ranged from 22-74 years old, and all cases were confirmed by pathology after the operation

Similar content being viewed by others Introduction Cancer stem-like cells (CSCs) or tumor-initiating cells are a distinct subpopulation with specific surface markers that possess the metastatic capability of undergoing unlimited cell growth, self-renewal, asymmetric cell division, and differentiation 1 The difference in radiosensitivity may be attributed to tumor heterogeneity, which is responsible for the inconsistent effect of radiation therapy on tumor cells 2 Furthermore, the radio-resistance of tumor cells, particularly CSCs, makes it difficult to eradicate the tumor, suggesting that it is essential to understand the mechanism of radio-resistance 3,4