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2 Veyssiere et al., PNAS (2015)Retro-inverso and short spadin analogs (including PE-22-28) as optimized TREK-1 blockers with antidepressant activity in mice

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"We cannot recommend peptide therapies that lack regulatory approval and adequate clinical trial evidence," stated the AACE 2023 obesity guideline update, which specifically addressed the proliferation of unapproved compounded peptides for weight management [9]

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doi: 10.1016/j.bulcan.2018.11.016