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In fact, in the CNS infiltrated peripheral myeloid cells, inflammatory signaling (pSTAT3) is significantly higher than in the CNS resident ones from the beginning to the peak of EAE (144)

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In fact, the overexpression of mitochondrial GPx4, but not nonmitochondrial GPx4, suppressed mitochondrial oxidative stress (36) and apoptosis mediated by the mitochondrial pathway in rat basophile leukemia cells (RBL2H3 cells) (37), suggesting that nonmitochondrial GPx4 plays a limited role in mitochondria (38)

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Neuron 98 , 4966.e49 (2018)

Furthermore, in a stroke animal model, erinacine A led to the suppression of reactive nitrogen species and the downregulation of iNOS, p38 MAPK, and CHOP, which are factors involved in ischemia injury