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Parkin deficiency compromises mitochondrial function in Drosophila [39], mice [40], and iPSC-derived neurons from individuals with Parkin PD [41]

Xue M, Han L, Qian W, Li J, Qin T, Xiao Y, Ma Q, Ma J, Shen X

PLoS ONE 9 , e113939 (2014)

Animal models have demonstrated increased ammonia levels lead to intracellular production of reactive oxygen species, induction of cellular apoptosis in bovine epithelial cells, increased inflammatory cytokines and repression of DNA repair-related genes in porcine Type II alveolar epithelial cells 48, 49

chinensis extract exhibits a possibility in managing and preventing oxidative stress-associated diseases such as hemorrhagic cystitis by cyclophosphamide with the normalization of the biochemical changes in urothral tissues, detrusor muscle leading to the reduction of DO (Juszczak et al., 2022)