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Interestingly, the authors observed significant UFA changes in the CB of AD patients relative to CN suggesting that metabolic alterations are systemic affecting multiple brain regions irrelevant of the presence of A and/or tau pathology

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In addition, muscle mass loss is coupled with reduced functionality, resulting in significant worsening of life quality and survival and, at the end-stage of disease, can lead to sudden death due to respiratory and/or cardiac failure (Sartori, Romanello and Sandri, 2021)