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September 6, 2012

One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition

Dietary recommendations for fatty liver disease include: Reducing intake of refined carbohydrates and added sugars, particularly fructose-containing beverages Limiting saturated fats whilst incorporating healthy fats from sources like olive oil, nuts, and oily fish Increasing consumption of fruits, vegetables, and whole grains Following a Mediterranean-style diet, which has shown particular benefit in NAFLD Limiting alcohol consumption in line with UK Chief Medical Officers' guidance (maximum 14 units per week spread over at least three days, with several alcohol-free days), or abstaining completely if advised by your clinician Physical activity provides benefits independent of weight loss

Intriguingly, some of the benefits of Omega-3 PUFA could be attributed to its modulatory role on gut microbiota

Nature (2014) 505:33543

Gastroenterology 160 (2), 524537