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Vildagliptin improves high glucose-induced endothelial mitochondrial dysfunction via inhibiting mitochondrial fission

10.1038/s41598-021-94607-5 6 BuscarinuM

All macromolecule and ligand interactions examined by molecular docking are in good agreement with enzymatic studies, and drug likeness data provide preliminary information on the availability of phytochemicals for drugs

Crucially, these findings stem primarily from small, heterogeneous studies using non-standardized extracts/doses, lack robust evidence, and focus on biochemical or symptomatic surrogates rather than clinically relevant hard endpoints, such as endoscopic remission, reduced hospitalizations, or avoidance of surgery

GABA serves as a non-toxic osmolyte, effectively mitigating ROS and thereby augmenting stress tolerance in plants (Carillo 2018)

PloS One (2009) 4(4):e5209