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TMLHE encodes the first enzyme in carnitine biosynthesis, N6-trimethyllysine dioxygenase (TMLD), which suggests that carnitine levels are important in ASD as well as cognitive and social functioning

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have shown that ALC supplementation (0.3, 0.6 and 1.2 mM for 5 h and 24 h) in mouse fibroblast culture media stabilizes the mitochondrial membrane, increases energy supply to the organelle and protects the developing cell from apoptosis through the mitochondrial pathway [57]

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It has been demonstrated that acetylation of some lysine of CAC inhibits the uptake of carnitine into mitochondria and hence negatively affect FAO (Figure 2), is activated by acetylation (Palmieri et al., 2015)

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