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Although methotrexate was first introduced as an antiproliferative agent that inhibits the synthesis of purines and pyrimidines for the therapy of malignancies, it is now clear that many of the anti-inflammatory effects of methotrexate are mediated by adenosine

S., Kim, N., Choi, H.-D

RyR2 is the largest known ion channel and also one of the first substrates to undergo phosphorylation during the fight-or-flight response (adrenergic stimulation) 1