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The FPA value was determined by measuring the absorbance at an excitation wavelength of 485 nm and emission wavelength of 528 nm and calculated according to the following formula: In competitive inhibition experiments, increasing concentrations of inhibitor peptides were titrated with a mixture of 120 nM FHD and 10 nM FITC-p53 TAD PEP

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In the early stage of SG fibrosis, reduced acini, architectural malformation and ductal dilation could be observed under the microscope

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Furthermore, limited toxicological data on aptamers in humans raises safety concerns, particularly as few aptamer-based therapies have reached clinical application