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Targeting tumor and cancer stem-like cells metabolism Simultaneously targeting tumors and cancer stem-like cells metabolic dependencies can reduce immune suppression and sensitize tumors to immune attack, with OXPHOS inhibitors such as IACS-010759, a complex I inhibitor, and phenformin disrupting mitochondrial respiration and preferentially impairing cancer stem-like cells that rely on OXPHOS [120]

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At Visit 2, participants were randomized in a 1:1:1:1 ratio in four different arms: placebo, 2.4 g of actives, 4.8 g of actives, 7.2 g of actives