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Figure 2 2 Atherosclerosis AS is a multifocal, immune-mediated chronic inflammatory disease that predominantly affects large and medium-sized arteries and is closely associated with lipid deposition

A recent study explored the mechanisms underlying the functional impairment and metabolic reprogramming of T lymphocytes in multiple myeloma and found silencing SLC38A2 resulted in decreased glutamine uptake and immune dysfunction of T cells [198]

Such strategies have been shown to increase drug concentration at the site of action, bypass resistance mechanisms, and minimize off-target toxicity [535,536,537]

Carter and Duax 2002

This work was supported by funds from the Department of Defense Autism Spectrum Disorders Research Program AS073224P2, the Autism Research Institute and the NYS Office for People with Developmental Disabilities

Drug Metab Rev