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These approaches include competitive inhibition via nucleotide analogs, blockade of precursors or biosynthetic enzymes, and disruption of folate and broader amino acid-driven metabolic networks [43]

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doi: 10.3389/fimmu.2018.01956 Received 09 May 2018 Accepted 08 August 2018 Published 12 September 2018 Volume 9 - 2018 Edited by Marcello Chieppa, Ospedale Specializzato in Gastroenterologia Saverio de Bellis (IRCCS), Italy Reviewed by Paola Allavena, Humanitas Clinical and Research Center, Italy