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EGFR activation leads to an intracellular signaling cascade via Ras activation, which stimulates the extracellular signal pathway-regulated kinase/mitogen-activated protein kinase pathway

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doi: 10.1016/j.redox.2017.11.001 56 ZhaoW.ZhangL.ChenR.LuH.SuiM.ZhuY.et al

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Animal-derived materials are complex undefined mixtures and are recognized as significant risks for stable cultivation and clinical application since they have lot-to-lot variations and risk of immunogenic contamination

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visualization: all authors

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Thioredoxin inhibition The dysregulated TRX system often drives tumor progression and therapy resistance, making its targeted inhibition a potent ROS-mediated anticancer strategy

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