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Abbreviations AINI: Alberta Idealised Nasal Inlet ATCC: American Type Cultural Collection BAX: B-cell lymphoma 2 associated X BCL-2: B-cell lymphoma 2 CC3: cleaved Caspase-3 CLT: cholesterol CQA: critical quality attributes CUR: curcumin DL: drug loading DLS: dynamic light scattering DMEM/F12: Dulbeccos Modified Eagle Medium/Nutrient Mixture F-12 DMEM: Dulbeccos Modified Eagles Medium DSC: differential scanning calorimetry DoE: Design of Experiment EE: encapsulation efficiency EtOH: ethanol F-12K: Kaighns Modification of Hams F-12 FBS: fetal bovine serum FIN: fingolimod FTIR: Fourier-transform infrared spectroscopy IN: intranasal IV: intravenous MCAO: middle cerebral artery occlusion MEM: Minimum Essential Medium MeOH: methanol MIVM: multi-inlet vortex mixer MRI: magnetic resonance imaging NGI: next generation impactor PBS: phosphate-buffered saline PDI: polydispersity index PVP: Polyvinylpyrrolidone PXRD: powder x-ray diffractometry RdI: redispersibility index Re: Reynold number S.D.: standard deviation TEM: transmission electron microscopy TFA: trifiuoroacetic acid TGA: thermogravimetric analysis UPW: ultra-purified water References Katan M, Luft A

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