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doi: 10.7150/ijbs.107837

This lack of response to GW7647 has been previously attributed to the downregulation of Ppara in the liver 6h after CLP ( Liver-i-KO mice, both in sham and CLP, compared to Hnf4a flfl mice, but not in Hnf4a flfl mice 8h after CLP ( Figure 2F ), but was decreased at later stages of sepsis, between 24h and 96h after CLP ( Figure 2G )

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These injections are either subcutaneous or intramuscular and best received 1-3 times a week

In terms of lifestyle interventions, high-intensity interval exercise has been found to enhance mitochondrial activity, whereas calorie-restricted diets have been demonstrated to contribute to slowing the aging process (Chong et al., 2021)

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