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Postmenopausal osteoporosis (OVX) rat model: After 12 weeks of AOD 9604 treatment, the number of osteoclasts decreased by 35%, CTX levels decreased by 40%, and bone resorption rate decreased by 50%

This modification weakened the nuclear translocation ability of NF-B and led to reduced expression of target genes Snail and YY1 [161]

Lindschinger M, Wonisch W

Results: Of the 3956 citations retrieved, a total of 5 randomized control trials including 2775 children were included in the review

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