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Estimated Glomerular Filtration Rate (eGFR) and Disease Stage 48 In stage 1 , the eGFR is within normal limits (90 mL/min/1.73 m 2 ) and the kidneys are still working adequately, but the presence of protein in the urine is indicative of mild kidney damage

Its history began with a breakthrough by a research team at the University of Texas, USA, in 2017.At that time, NNMT was recognized as a key enzyme in cellular metabolism and energy homeostasis, highly active in adipose tissue and closely linked to obesity, type 2 diabetes, and other metabolic diseases

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Lang FM, Mo Y, Sabbagh M, Solomon P, Boada M, Jones RW, Frisoni GB, Grimmer T, Dubois B, Harnett M, Friedhoff SR, Coslett S, Cummings JL, et al

10.1038/s41419-022-05137-5 4

Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors