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The alanine substitution does not abolish copper binding but does modify the geometry, the binding affinity, and the biological characterization of the complex

Iranian J Health Sci 6(1):2532 Rocha JE, Guedes TTAM, Bezerra CF, Costa MdS, Campina FF, de Freitas TS, Souza AK, Sobral Souza CE, de Matos YMLS, Pereira-Junior FN, da Silva JH, Menezes IRA, Teixeira RNP, Colares AV, Coutinho HDM (2019) Identification of the gallic acid mechanism of action on mercury chloride toxicity reduction using infrared spectroscopy and antioxidant assays

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Most of the reports currently described show that resistant leukemic cells have enhanced mitochondrial activity, while other works suggest that impaired or stable mitochondrial activity could be related to resistance