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doi: 10.1590/0001-3765202420230559 35

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Several studies have reported that more than one strategy is needed to address the delivery challenges

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And so I thought, oh my gosh, this is really interesting, because every time I would do the same dance, even though I thought I was doing the same thing, I looked completely different from the other Janies because that time I stretched the music here or my demeanor was softer there

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Together, these findings demonstrate that, in contrast with acute exposure, chronic disruption of iron homeostasis with consequent GSH depletion remodels cellular redox homeostasis over time, inducing a state we term chronoferroptosis: a persistent ferroptotic adaptation characterized by coordinated alterations in iron-handling and antioxidant defense proteins that may represent early vulnerability to neurodegenerative pathology

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Neurology 73(18):14691477

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